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DERIVADOS DE CICLOHEXANO SUSTITUIDO CON AMIDO
专利权人:
BAYER PHARMA AKTIENGESELLSCHAFT
发明人:
EIS, Knut,ACKERSTAFF, Jens,WAGNER, Sarah,BUCHGRABER, Philipp,SULZLE, Detlev,HOLTON, Simon,BENDER, Eckhard,LI, Volkhart min-Jian,LIU, Ningshu,SIEGEL, Franziska,LIENAU, Philip,BAIRLEIN, Michaela,NUSSBAU
申请号:
PE0023712017
公开号:
PE10242018A1
申请日:
2016.05.02
申请国别(地区):
PE
年份:
2018
代理人:
摘要:
Refers to compounds with amido substituted cyclohexane Derivatives of General formula (i), where a is a selected Group of A1A2 or A3, A3 is a Aromatic bicyclic Ring System, where C is a heteroaryl Group of 5 members containing heteroatoms (n,NH n alkyl or C1 - C3) and D is a phenyl or heteroaryl Group of 6 members containing nitrogen hetero OR13 r1 is - - N (R14 and R15) R13 is c1-c6 alkyl, cycloalkyl C3 C6Hidroxialquilo C2 - C6, among others R14 and R15 are Hydrogen, C1 - C6 alkyl, cycloalkyl C3 C6, among others R2 is H, alkyl or cycloalkyl C1 - C3 - C4 C3 R4 is Hydrogen R6 is Hydrogen, halogen,Hydroxy, among others R7 is Hydrogen or Halogen R8 is Hydrogen or alkyl C1 - C3 R9 is Hydrogen, halogen, alkoxy C1 - C3, among other R10 is Hydrogen, alkyl, cycloalkyl C1 - C3, C3 - C4Among others, R11 is a selected Group among both aryl and heteroaryl alkyl, optionally substituted with alkoxy - C1 - C6 C1, C3, C3 C6 cycloalkyl, among others.It also relates to a method for preparing such Compounds, Pharmaceutical compositions and combinations of intermediate Compounds, including compounds of formula (i).These compounds are inhibitors of tanquirasas tnks1 and \/ tnks2 and are useful in the Treatment or prophylaxis of Cell proliferative diseases such as hematology,Solid tumors and \/ or metastases of the same, among othersSe refiere a compuestos derivados de ciclohexano sustituido con amido de formula general (I), donde A es un grupo seleccionado de A1, A2 o A3 A3 representa un sistema de anillos aromaticos biciclicos, donde C es un grupo heteroarilo de 5 miembros que contiene heteroatomos N, NH o N(alquilo C1-C3) y D es un grupo fenilo o heteroarilo de 6 miembros que contienen heteroatomos de nitrogeno R1 es -OR13 y -N(R14)R15 R13 es alquilo C1-C6, cicloalquilo C3-C6, hidroxialquilo C2-C6, entre otros R14 y R15 son hidrogeno, alquilo C1-C6, cicloalquilo C3-C6, entre otros R2 es H, alquilo C1-C3 o cicloalquilo C3-C4 R4 es hidrogeno R6 es hidrogeno, halogeno, hidroxi, entre otr
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