SAITO, HIROSHI,斋藤博,齋藤博,KOMIYAMA, MASATO,小宫山真人,小宮山真人,OCHIAI, EIJI,落合锐士,落合銳士,TAKAGI, KENICHIRO,高木健一郎,CHIDA, TAKAYUKI,千田贵之,千田貴之,FUJITA, MARIKO,藤田真理子,IMAIZUMI, KEIICHIRO,今泉启一郎,今泉啟一郎,KANEKO, TO
申请号：
TW100138462
公开号：
TWI503120B
申请日:
2011.10.24
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
To provide a novel vitamin D 3 derivative useful as a therapeutic agent for osteoporosis. Provided is a vitamin D 3 derivative represented by the following formula (1) or a medicinally acceptable solvate thereof: wherein R 1 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, an alkylcarbonyloxyalkyl group with each alkyl having 1 to 6 carbon atoms, or an arylcarbonyloxyalkyl group with the aryl having 6 to 10 carbon atoms and the alkyl having 1 to 6 carbon atoms； R 2 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or, together with the other R 2 and the carbon atom to which they are bound to, may form a cyclic alkyl group having 3 to 6 carbon atoms； R 3 represents an alkyl group having 1 to 6 carbon atoms or, together with the other R 3 and the carbon atom to which they are bound to, may form a cyclic alkyl group having 3 to 6 carbon atoms； X represents an oxygen atom or a methylene group； and n represents an integer of 1 or 2.本發明係提供有用於作為骨質疏鬆症治療劑之新穎維生素D3衍生物。其係以下述式(1)表示之維生素D3衍生物或其醫藥上容許之溶劑合物。此處，R1表示氫原子、碳數1～6之烷基、烷基羰基氧烷基(各烷基之碳數為1~6)、或芳基羰基氧烷基(芳基之碳數為6~10、烷基之碳數為1~6)。R2表示氫原子或碳數1～6之烷基、或亦可與另一R2及該等所鍵結之碳原子一起形成碳數3～6之環狀烷基。R3表示碳數1～6之烷基、或亦可與另一R3及該等所鍵結之碳原子一起形成碳數3～6之環狀烷基。X表示氧原子或亞甲基、n表示1或2之整數。
