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נגזרות טטראהידרואיזוקוינולין, תכשירים המכילים אותן ושימוש בהן
专利权人:
DAIICHI SANKYO COMPANY LIMITED
发明人:
申请号:
IL20816810
公开号:
IL208168A
申请日:
2010.09.15
申请国别(地区):
IL
年份:
2013
代理人:
摘要:
The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent DGAT inhibitory effect and feeding suppressant effect. The present invention provides a compound represented by the general formula (I), or pharmacologically acceptable salt thereof: [wherein, R 1 represents a phenylaminocarbonyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group A, a benzoxazol-2-yl group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group A, or the like; R 2 independently represents a C 1 -C 6 alkyl group; R 3 represents a group represented by the formula -C(=O)-O-R 4 or the like; R 4 represents a hydrogen atom, a C 1 -C 6 alkyl group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group B, or the like; X represents an oxygen atom, a methylene group, or a group represented by the formula -NH-, or the like; L represents a single bond, a methylene group, or the like;...... represents a single bond or a double bond; m represents 1 or 2; n represents an integer of 0 to 5; Substituent Group A represents a halogen atom, a C 1 -C 6 alkyl group, a C 1 -C 6 halogenated alkyl group, a C 1 -C 6 alkoxy group, or the like; and Substituent Group B represents a C 3 -C 6 cycloalkyl group, a phenyl group, a carboxyl group, or the like].
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