The present invention relates to a heart valve prosthesis (1) comprising a plurality of flexible valve leaflets (3), and a stent (2) for holding said valve leaflets (3). According to the present invention, the heart valve prosthesis (1) comprises at least one piezo element (5) and/or a member (7) with a bimetallic portion for generating at least one signal (U) indicative of operativeness of the heart valve prosthesis (1).