Joseph P. Dougherty,Sofiya Micheva-Viteva,Stuart W. Peltz,Yacov Ron,Annmarie Pacchia
申请号:
US13551257
公开号:
US09017935B2
申请日:
2012.07.17
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Isolated, latently infected T cell lines are provided that can be utilized in high throughput screening to discover compounds capable of activating HIV-I. The T cell lines harbor a latent HIV-I derived vector pro virus, which upon activation expresses a marker for late viral gene expression due to the insertion of the marker gene in the position of HIV-I envelope.