The present invention relates to a composition comprising caspofungin or a pharmaceutical acceptable salt thereof and pharmaceutical acceptable lactate buffer agent. By adding the lactate buffer agent can greatly reduce the generation of caspofungin degradation products, which makes the stability of caspofungin greatly improved. The composition is convenient for preservation and clinical use, so as to improve the safety.本發明涉及一種醫藥組成物,其含有卡泊芬淨或其藥學上可接受的鹽,以及藥學上可接受量的乳酸鹽緩衝劑,藉由加入乳酸鹽緩衝劑,極大地減小了卡泊芬淨降解產物的產生,使得卡泊芬淨的穩定性大大提高,方便了保存和臨床使用,從而提高了卡泊芬淨使用的安全性。