PHARMACEUTICAL COMBINATION, METHODS TO TREAT MYOTIC INFECTION, TO PREVENT MYOTIC INFECTION, TO TREAT INVASIVE PULMONARY ASPERGILLOSIS AND TO REDUCE GALACTOMANAN LEVELS, DRUG PREPARATION, AND, USE OF PHARMACEUTICAL COMBINATION.
the present invention relates to the use of trumpenoidal antifungal compounds derived from enfumafungin in combination with other antifungal agents, such as azois, polyenes, lipopetides and allylamines, to treat fungal diseases. more particularly, the invention relates to antifungal combinations of trumapenes derived from enfumafungin, which are inhibitors of (1,3) -beta-d-glucan synthesis, in combination with other antifungal agents such as active agents for mold that have activity against molds including but not limited to voriconazole, isavuconazole, posaconazole, itraconazole and amphotericin b, for the treatment and / or prevention of infections caused by mold.a presente invenção se refere ao uso de compostos antifúngicos triterpenoides derivados de enfumafungina em combinação com outros agentes antifúngicos, tais como azois, polienos, lipopetídeos e alilaminas, para tratar doenças fúngicas. mais particularmente, a invenção se refere às combinações antifúngicas de triterpenoides derivados de enfumafungina, que são inibidores de síntese de (1,3)-beta-d-glucano, em combinação com outros agentes antifúngicos tais como agentes ativos para bolor que apresentam atividade contra bolores incluindo, mas sem limitação voriconazol, isavuconazol, posaconazol, itraconazol e anfotericina b, para o tratamento e/ou prevenção de infecções causadas por bolores.
