François Paul Bischoff,Henricus Jacobus Maria Gijsen,Frans Alfons Maria Van den Keybus,Frederik Jan Rita Rombouts
申请号：
US14654397
公开号：
US10112943B2
申请日:
2013.12.19
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention is concerned with novel tricyclic 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione derivatives of Formula (I)wherein R1, R2, R3, R4, L, Y, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
