תולדות של n–(2, 3 –דיהידרו – 1h–פירולו [3,2–b] פירידינ– 5–יל) – 4–קווינאזולינאמין ו– n–(2, 3–דיהידרו –1h – אינדול– 5 –יל} – 4 –קווינאזולינאמין כמעכבי perk

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专利权人:

JANSSEN PHARMACEUTICA NV

发明人:

申请号：

IL24180815

公开号：

IL241808A

申请日:

2015.09.24

申请国别(地区):

IL

年份:

2018

代理人:

摘要：

The present invention relates to N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and A have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors of PERK. The invention further relates to processes for preparing such compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

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中国工程科技知识中心

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