RABOISSON, PIERRE JEAN-MARIE BERNARD,DE KOCK, HERMAN AUGUSTINUS,SIMMEN, KENNETH ALAN,JONSSON, CARL ERIK DANIEL,NILSSON, KARL MAGNUS,ROSENQUIST, ASA ANNICA KRISTINA,SAMUELSSON, BENGT BERTIL,ANTONOV, DM
申请号：
CA2617096
公开号：
CA2617096C
申请日:
2006.07.28
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Inhibitors of HCV replication of formula (I) and the N-oxides, salts, orstereoisomers thereof, wherein each dashed line (represented by ------)represents an optional double bond； X is N, CH and where X bears a double bondit is C； R1 is -OR6, -NH-SO2R7； R2 is hydrogen, and where X is C or CH, R2 mayalso be C1-6alkyl； R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, or C3-7cycloalkyl； n is 3, 4, 5, or 6； R4 and R5 independently from one another arehydrogen, halo, hydroxy, nitro, cyano, carboxyl, C1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, C1-6alkylcarbonyl, C1-6alkoxy- carbonyl, amino, azido,mercapto, C1-6alkylthio, polyhaloC1-6alkyl, aryl or Het； W is aryl or Het； R6is hydrogen； aryl； Het； C3-7cycloalkyl optionally substituted with C1-6alkyl；or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het； R7is aryl； Het； C3-7cycloalkyl optionally substituted with C1-6alkyl； or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het； aryl isphenyl or naphthyl, each optionally substituted with 1-3 substituents； Het isa 5 or 6 membered saturated, partially unsaturated or completely unsaturatedheterocyclic ring containing 1 - 4 heteroatoms each independently selectedfrom N, O or S, and optionally substituted with 1 -3 substituents；pharmaceutical compositions containing compounds (I) and processes forpreparing compounds (I). Bioavailable combinations of the inhibitors of HCV offormula (I) with ritonavir are also provided.
