CANALES, EDA,CHONG, LEE S.,CLARKE, MICHAEL O&APOSNEIL HANRAHAN,DOERFFLER, EDWARD,LAZERWITH, SCOTT E.,LEW, WILLARD,MERTZMAN, MICHAEL,MORGANELLI, PHILIP ANTHONY,WATKINS, WILLIAM J.
申请号：
PE0010042012
公开号：
PE15222012A1
申请日:
2011.01.14
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Relates to compounds of formula (i) where R1 is alkyl - 12 alquenilo C1, C2 - C3 - 12 12, cycloalkyl, aryl c6-14, among others, optionally substituted with Rust, Oxo, among others R2 is alkyl - 12 alquenilo C1, C2 - C6 arylalkyl 12, 18, heterociclilo C3 - 12 other, Optionally substituted S, - NO2 - N (= OR), among others and R3 is het - - L -, N - (R4) (R5 or R6) = nor7 R3 is alquileno C - 12Cicloalquilalquileno C3 - 12, among others R4 is H, alkyl C1 - C3 - heteroaryl 12, 14, among others R5 is heteroaryl alkyl C1 - C3 - 12, 14, among others alquilino R6 is C1 - C3 - cicloalquilino 12 12 12 heterociclilino C3 or optionally substituted alkyl R7 is C1 - 12, aryl c6-14, among others L - or C (o) n (R4) -, - C (o) -,Among others Het is heterociclilo C3 C3 - 14 - 12 or optionally substituted heteroaryl.Preferred compounds are: Ester 2 - oxo - pyrrolidin-3-yl - 3 - (R) - ilico acid 3 - (S) - 2 - [[5 - Carboxy - (3,3 - dimethyl - - 1 - - but inil) - yl] thiophene-3 (Trans - 4 - methyl - amino ciclohexanocarbonil) - pyrrolidine] - 1 - carboxylic acid, 5 - (3,3 - dimethyl - but - 1 - inil) - 3 - (4 - methyl - ciclohexanocarbonil trans) - pyridin - [4 - (2 - ilmetoxiimino ) cyclohexyl] amino} - tiofen - 2 - carboxylic acid among others.In addition to such a Pharmaceutical composition. These compounds are useful for treating Flaviviridae infectionsSE REFIERE A COMPUESTOS DE FORMULA (I) DONDE: R1 ES ALQUILO C1-12, ALQUENILO C2-12, CICLOALQUILO C3-12, ARILO C6-14, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON OXIDO, OXO, ENTRE OTROS R2 ES ALQUILO C1-12, ALQUENILO C2-12, ARILALQUILO C6-18, HETEROCICLILO C3-12 ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON, -NO2, -N(=O), ENTRE OTROS Y ES -R3-L-HET, -N(R4)(R5) O -R6=NOR7 R3 ES ALQUILENO C-12, CICLOALQUILALQUILENO C3-12, ENTRE OTROS R4 ES H, ALQUILO C1-12, HETEROARILO C3-14, ENTRE OTROS R5 ES ALQUILO C1-12, HETEROARILO C3-14, ENTRE OTROS R6 ES ALQUILINO C1-12, CICLOALQUILINO C3-12 O HETEROCICLILINO C3-12 OPCIONALMENTE SUSTITUIDOS R7 ES AL
