OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU "PHARMENTERPRISES"
发明人:
Vladimir Evgenievich NEBOLSIN,Tatyana Alexandrovna KROMOVA,Anastasia Vladimirovna RYDLOVSKAYA
申请号：
MX2019006880
公开号：
MX2019006880A
申请日:
2018.05.24
申请国别(地区):
MX
年份:
2019
代理人:
摘要：
The invention relates to chemistry of organic substances, pharmacology and medicine, and concerns treating diseases associated and with aberrant activity of cells of the immune system, more particularly for treating lung, respiratory tract and abdominal diseases, radiation sickness, pain syndrome and other diseases by using compounds of formula (A), wherein R1 is a -C(O)-R2-C(O)- or -R2-C(O)- group, where R2 is a -(CH2)n- group optionally substituted with one or two C1-C6 alkyls, or phenyl, and n is an integer from 0 to 4； wherein the compounds are selected from a group consisting of the compounds as set out in the description. These compounds, as well as pharmaceutically acceptable salts thereof, are highly effective in inhibiting glutaminyl cyclase, which is involved, in particular, in post-translational modification of chemokines and chemotaxis of monocytes, macrophages and other cells of the immune system. This invention also relates to pharmaceutical compositions comprising a therapeutically effective amount of the compounds of formula (A) as defined above.La invencion se refiere a la quimica de sustancias organicas, farmacologia y medicina, y se relaciona al tratamiento de enfermedades asociadas y con la actividad aberrante de celulas del sistema inmune, mas particularmente para el tratamiento de enfermedades del pulmon, del tracto respiratorio y abdominales, malestar por radiacion y sindrome de dolor, y tambien otras enfermedades al utilizar compuestos de formula (A) [ver fórmula (A)] en donde R1 es un grupo -C(O)-R2-C(O)- o -R2-C(O)-, donde R2 es un grupo -(CH2)n- opcionalmente sustituido con uno o dos alquilos de C1-C6, o fenilo, n es un entero de 0 a 4； en donde los compuestos se seleccionan del grupo que consiste del grupo de compuestos como se establece en la descripcion； estos compuestos, asi como las sales farmaceuticamente aceptables de los mismos, son altamente eficaces para inhibir la glutaminil ciclasa, que esta involucrada, en particular, en proce
