BERTRAND, MYRA BEAUDOIN,SHI, QING,WATTERSON, SCOTT HUNTER,BATT, DOUGLAS G.,TINO, JOSEPH A.,DELUCCA, GEORGE V.,GALELLA, MICHAEL A.,KO, SOO SUNG,SRIVASTAVA, ANURAG S.,LIU, QINGJIE
申请号：
PE0026652015
公开号：
PE05192016A1
申请日:
2014.06.25
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
Described are compounds of the formula (i), wherein: The two dotted Lines represent two Simple Links or two double Bonds Q is a), b), c) and d), where R1 is H, or C1 cn CH3 CH3 is C1 R2 or R3 is c - (CH2) 2OH or CH2 CH2OH ra is H or CH3 is independent each RB F, C1, and \/ or - CH3 - ol H3 and N is 0, 1 or 2.It also describes methods for using such compounds as inhibitors of the tyrosine kinase Bruton (BTK), and Pharmaceutical compositions comprising such compounds. These compounds are useful for treating, preventing or slowing the progression of diseases or disorders in several Therapeutic areas, such as autoimmune diseases and vascularSe describen los compuestos de la Formula (I), en donde: las dos lineas punteadas representan dos enlaces simples o dos enlaces dobles Q es a), b), c) o d), en donde R1 es F, C1, -CN o -CH3 R2 es C1 o -CH3 R3 es -C(CH2) 2OH o CH2 CH2OH Ra es H o-CH3 cada Rb es independiente F, C1, -CH3 y/o -OCH3 y n es cero, 1 o 2. Tambien describen metodos para usar tales compuestos como inhibidores de la tirosina cinasa de Bruton (Btk), y composiciones farmaceuticas que comprenden tales compuestos. Estos compuestos son utiles para el tratamiento, la prevencion o la ralentizacion de la progresion de enfermedades o trastornos en varias areas terapeuticas, tales como enfermedades autoinmunes y vasculares
