David M. Lynn,Ronald T. Raines,Christopher M. Jewell,Stephen M. Fuchs,Ryan M. Flessner
申请号：
US12017953
公开号：
US08834918B2
申请日:
2008.01.22
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A composition for delivery of a molecule into a cell is provided. The composition includes a protein transduction domain that is conjugated to the molecule which is incorporated into a multilayered film. Preferably, the protein transduction domain is a cationic protein transduction domain. More preferably, the cationic protein transduction domain is nonaarginine, and the multilayered film includes polyelectrolyte multilayers. When the composition is presented to a cell, the multilayered film dissolves or erodes in physiological media, and the molecule is delivered into the cell.
