<;P>;PROBLEM TO BE SOLVED: To provide a composition and a device, suitable for introducing a physiologically active drug to the ocular tissue by utilizing ultrasonic energy. <;P>;SOLUTION: The composition for introducing the physiologically active drug to the ocular tissue contains the physiologically active drug to be introduced and microspheres including microbubbles. The ultrasonic irradiation device is suitable for introduction of the physiologically active drug to the ocular surface tissue or the ocular internal tissue. <;P>;COPYRIGHT: (C)2007,JPO&INPIT