The present invention provides an ophthalmic pharmaceutical composition having a certain pH, comprising aflibercept as an active ingredient； an acetate salt buffering agent, wherein the ophthalmic pharmaceutical composition is free of an ionic tonicity agent. The ophthalmic pharmaceutical composition of the present invention can remarkably reduce the formation of dimeric and multimeric impurities and maintain the biological activity in a high level for a long time under the accelerated and stress conditions as well as under the cold storage condition.本發明提供一種具有特定pH值之眼用藥用組合物，其包含作為活性成分之阿柏西普、一醋酸鹽緩衝劑，其中，該眼用藥用組合物不含離子滲壓劑。於加速條件與壓力條件以及低溫儲存條件下，本發明之眼用藥用組合物可明顯減少二聚體與多聚體雜質之形成，並可長時間維持高生物活性。
