The present invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivative of -phenyl -2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions comprising them, combinations and therapeutic uses thereof (I) wherein n is O or 1 R1 and R2 may be the same or different, and are selected from the group consisting of: - linear or branched C1-C6 alkyl - OR3 wherein R3 is C1-C6 alkyl optionally substituted by one or more C3-C7 cycloalkyl groups and - HNSO2R4 wherein R4 is C1-C4 alkyl optionally substituted with one or more halogen atoms or with a C1-C4 group, wherein at least one of Rl and R2 is HNSO2R4. The other variables are as defined in the claims.
