LONBERG Nils,KORMAN Alan J.,BARNHART Bryan C.,YAMNIUK Aaron P.,SRINIVASAN Mohan,HENNING Karla A.,LEI Ming,SEGA Emanuela,GOODENOUGH Angela,JURE-KUNKEL Maria N.,CHEN Guodong,SACK John,HUANG Richard,CORB
申请号：
SI201531307
公开号：
SI3221363T1
申请日:
2015.11.19
申请国别(地区):
SI
年份:
2020
代理人:
摘要：
The present disclosure provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the disclosure, including methods for treating various cancers.
