Nils LONBERG,Alan J. KORMAN,Bryan C. BARNHART,Aaron P. YAMNIUK,Mohan SRINIVASAN,Karla A. HENNING,Ming LEI,Emanuela SEGA,Angela GOODENOUGH,Maria JURE-KUNKEL,Guodong CHEN,John S. SACK,Richard Y. HUANG,M
申请号：
US15520638
公开号：
US20180127513A1
申请日:
2015.11.19
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present disclosure provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the disclosure, including methods for treating various cancers.
