LONBERG, Nils,Korman, Alan J.,BARNHART, Bryan C.,YAMNIUK, Aaron P.,SRINIVASAN, Mohan,HENNING, Karla A.,LEI, Ming,SEGA, Emanuela,GOODENOUGH, Angela,JURE-KUNKEL, Maria N.,CHEN, Guodong,SACK, John,HUANG,
申请号：
DK15816276
公开号：
DK3221363T3
申请日:
2015.11.19
申请国别(地区):
DK
年份:
2020
代理人:
摘要：
The present disclosure provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the disclosure, including methods for treating various cancers.
