Dong Wang,Jindrich Kopecek,Scott C. Miller,Pavla Kopeckova
申请号：
US10591258
公开号：
US10092662B2
申请日:
2005.03.30
申请国别(地区):
US
年份:
2018
代理人:
摘要：
This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.
