New process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

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专利权人:

LES LABORATOIRES SERVIER

发明人:

GONZALEZ JOSE LORENZO,SANCHEZ FREDERIC,CARRANZA MARIA DEL PILAR,GARCIA ARANDA MARIA ISABEL

申请号：

NZ61864413

公开号：

NZ618644A

申请日:

2013.12.05

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

618644 Disclosed herein is a process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile from 1-bromo-2-(bromomethyl)-4,5-dimethoxybenzene. The process uses a base in the presence of acetonitrile in an organic solvent. Also disclosed is the use of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile in the synthesis of ivabradine.

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