NEW PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID

• 收藏
• 分享

专利权人:

发明人:

레나우드, 장-루크,파네티에르, 니콜라스,가일라드, 실바인,레코우브, 장-피에르,바이세-루도트, 루시리

申请号：

KR1020120148761

公开号：

KR1014799860000B1

申请日:

2012.12.18

申请国别(地区):

KR

年份:

2015

代理人:

摘要：

Synthesis of ivabradine involves subjecting 3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-propionaldehyde to a reductive amination reaction with ((S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1,2,4-trien-7-ylmethyl)-methyl-amine in presence of formic acid (greater than 1 equivalent per equivalent of aldehyde) and of triethylamine (greater than 1 equivalent per equivalent of aldehyde), at 15-100[deg] C, in absence of solvent/alcoholic solvent. ACTIVITY : Cardiant； Antianginal； Cardiant； Cardiant. No biological data given.본 발명은 하기 화학식(I)의 이바브라딘, 약제학적으로 허용되는 산과의 이의 부가염, 및 이의 수화물을 합성하는 방법 및 약물에 관한 것이다:

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/