IMIDAZOTHIAZOLE DERIVATIVES HAVING PROLINE RING STRUCTURE

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专利权人:

发明人:

UOTO KOUICHI,SUGIMOTO YUUICHI,NAITO HIROYUKI,MIYAZAKI MASAKI,YOSHIDA KEISUKE,AONUMA MASASHI

申请号：

IN1543/MUMNP/2011

公开号：

IN2011MN01543A

申请日:

2011.07.22

申请国别(地区):

IN

年份:

2012

代理人:

摘要：

[Problem to be solved] There is provided a novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity. [Solution] The present invention provides an imidazothiazole derivative represented by the following formula (1) having various substituents that inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity: wherein R1, R2, R3, R4, R5, R6, R7, Ar1, and Ar2 in formula (1) respectively have the same meanings as defined in the specification.

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