Yuuichi Sugimoto,Kouichi Uoto,Takanori Wakabayashi,Masaki Miyazaki,Masaki Setoguchi,Toru Taniguchi,Keisuke Yoshida,Akitake Yamaguchi,Shoko Yoshida
申请号：
US13416061
公开号：
US20130165424A9
申请日:
2012.03.09
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.
