DISPIROPYRROLIDINE DERIVATIVE

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专利权人:

DAIICHI SANKYO COMPANY; LIMITED

发明人:

SUGIMOTO, Yuuichi,UOTO, Kouichi,MIYAZAKI, Masaki,SETOGUCHI, Masaki,TANIGUCHI, Toru,YOSHIDA, Keisuke,YAMAGUCHI, Akitake,YOSHIDA, Shoko,WAKABAYASHI, Takanori

申请号：

HUE12755073

公开号：

HUE038714T2

申请日:

2012.03.09

申请国别(地区):

HU

年份:

2018

代理人:

摘要：

A novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1) having various substituents that inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R 1 , R 2 , R 3 , ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/