The invention relates to a disinfection device (1) for plasma disinfection ofsurfaces comprising aplasma generator (2) for generating a disinfecting plasma gas stream (PA), andcomprising an atleast partially closed disinfection area (5) that is in communicatingconnection with the plasmagenerator (2), which is configured for receiving the surface (6) to bedisinfected. The disinfectiondevice (1) has an aerosol generator (9) for generating an aqueous aerosolstream (A) containingparticles. The aerosol generator (9) is in communicating connection with theplasma generator(2) in order to guide the plasma gas stream (PA) mixed with the aerosol stream(A) in thedisinfection area (5) onto the surface (6) to be disinfected.