BONFANTI, JEAN-FRANCOIS,FORTIN, JEROME MICHEL CLAUDE,DORANGE, ISMET
申请号：
CA2600507
公开号：
CA2600507C
申请日:
2006.03.17
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Novel 1,3-dihydro-benzimidazo l-2-ylidene amine derivatives of formula (I) theaddition salts and stereochemically iso meric forms wherein each Alk is C1-6alkanediyl； Q is hydrogen； C1-6alkyl subst ituted with one or two Ar2radicals； C1-66alkyl subst ituted with quinolinyl, oxazolidinyl,thiazolidinyl, morpholinyl, thiomorpholinyl, or with pyrrolidinonyl； -CO-Ar2；or Q is a radical of formula wherein t is 1, 2 or 3； R4 is amino, mono-ordi(C1-6alkyl)amino ； R1 is Ar2, -CO-Ar2 or a monocyclic or bicyclicheterocycle which may optionally be subst ituted； R2 is as R1 and additionallycan be hydrogen； where Q is other than hydrogen, R3 is hydrogen； and where Qis other than hydrogen, R3 is a radical: (b) wherein R6 is hydrogen, C1-6alkyl, substituted C1-6alkyl； R7, R8, R9 are halo, cyano, C1-6alkyl,substituted C1-6alkyl, C2-6alkenyl, cyanoC2-6alkenyl, C2-6alkynyl, cyanoC26alkynyl, Ar11, R10a-O-, R10a-S-, -N(R5aR5b), R10a-O-C(=O)-, N(R5aR5b)-C(=O)-,R10a-C(=O)-NR5b-, R10b-C(=O)-O-； and R8 and/or R9 may also be hydrogen； whichare RSV inhibitors. Compositions containing these compounds and processes forpreparing these compounds and compositions.
