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1,3-Dihydro-benzimidazol-2-ylideneamines as inhibitors of respiratory syncytium virus replication
专利权人:
テイボテク・フアーマシユーチカルズ
发明人:
ボンフアンテイ,ジヤン-フランソワ,フオルタン,ジエローム・ミシエル・クロード,ドランジ,イスメト,ボンフアンテイ,ジヤン-フランソワ,フオルタン,ジエローム・ミシエル・クロード,ドランジ,イスメト
申请号:
JP2008501332
公开号:
JP5289934B2
申请日:
2006.03.17
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
Novel 1,3-dihydro-benzimidazol-2-ylidene amine derivatives of formula the addition salts and stereochemically isomeric forms wherein each Alk is C1-6alkanediyl; Q is hydrogen; C1-6alkyl substituted with one or two Ar2 radicals; C1-6alkyl substituted with quinolinyl, oxazolidinyl, thiazolidinyl, morpholinyl, thiomorpholinyl, or with pyrrolidinonyl; —CO—Ar2; or Q is a radical of formula wherein t is 1, 2 or 3; R4 is amino, mono-or di(C1-6alkyl)amino; R1 is Ar2, —CO—Ar2 or a monocyclic or bicyclic heterocycle which may optionally be substituted; R2 is as R1 and additionally can be hydrogen; where Q is other than hydrogen, R3 is hydrogen; and where Q is other than hydrogen, R3 is a radical: wherein R6 is hydrogen, C1-6alkyl, substituted C1-6alkyl; R7, R8, R9 are halo, cyano, C1-6alkyl, substituted C1-6alkyl, C2-6alkenyl, cyanoC2-6alkenyl, C2-6alkynyl, cyanoC2 6alkynyl, Ar1, R10a—0—, R10a—S—, —N(R5aR5b), R10a—O—C(═O)—, N(R5aR5b)—C(═O)—, R10a—C(═O)—NR5b—, R10b—C(═O)—O—; and R8 and/or R9 may also be hydrogen; which are RSV inhibitors. Compositions containing these compounds and processes for preparing these compounds and compositions.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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