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Human immunodeficiency virus replication inhibitors
专利权人:
VIIV Healthcare UK (No.5) Limited
发明人:
WALKER, Michael,SORENSON, Margaret,NAIDU, B.,PEESE, Kevin,JOHNSON, Barry,PATEL, Manoj
申请号:
ES13705712
公开号:
ES2654173T3
申请日:
2013.02.14
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of Formula I ** (See formula) ** in which: R1 is hydrogen, alkyl, cycloalkyl, haloalkyl, (Ar2) alkyl, (Ar2) cycloalkyl, Ar2, alkylCO, cycloalkylCO, haloalkylCO, (Ar2) alkylCO, ((Ar2) cycloalkyl) alkylCO, (Ar2) cycloalkylCO, Ar2CO, (Ar2) alkylCOCO, Ar2COCO, alkylCO2, haloalkylCO2, (Ar2) alkylCO2, Ar2CO2, alkylCONH, haloalkylCONH, (Ar2) alkylCONH, Ar2CONHalkyl, alkylSO2 alkyl halo and Ar2SO2; or R1 is (PhCH2O) PhCH2CO, ** (See formula) ** R2 is alkyl or haloalkyl; R3 is alkyl; R4 is hydrogen or alkyl; R5 is hydrogen or alkyl; Ar1 is phenyl or chromanyl, and is substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, alkoxy and haloalkoxy; and Ar2 is phenyl, biphenyl or indolyl, and is substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkoxy and haloalkoxy; or a pharmaceutically acceptable salt thereof.Un compuesto de Fórmula I **(Ver fórmula)** en la que: R1 es hidrógeno, alquilo, cicloalquilo, haloalquilo, (Ar2)alquilo, (Ar2)cicloalquilo, Ar2, alquilCO, cicloalquilCO, haloalquilCO, (Ar2)alquilCO, ((Ar2)cicloalquil)alquilCO, (Ar2)cicloalquilCO, Ar2CO, (Ar2)alquilCOCO, Ar2COCO, alquilCO2, haloalquilCO2, (Ar2)alquilCO2, Ar2CO2, alquilCONH, haloalquilCONH, (Ar2)alquilCONH, Ar2CONH, alquilSO2, cicloalquilSO2, haloalquilSO2, y Ar2SO2; o R1 es (PhCH2O)PhCH2CO, **(Ver fórmula)** R2 es alquilo o haloalquilo; R3 es alquilo; R4 es hidrógeno o alquilo; R5 es hidrógeno o alquilo; Ar1 es fenilo o cromanilo, y está sustituido con 0-3 sustituyentes seleccionados entre halo, alquilo, haloalquilo, alcoxi y haloalcoxi; y Ar2 es fenilo, bifenilo o indolilo, y está sustituido con 0-3 sustituyentes seleccionados entre halo, alquilo, haloalquilo, cicloalquilo, halocicloalquilo, alcoxi y haloalcoxi; o una sal farmacéuticamente aceptable del mismo.
来源网站:
中国工程科技知识中心
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