經修飾之脂質化鬆弛素B鏈胜肽及其治療用途农业专利-农业学术服务平台

发明人:: BRASSEUR, DENIS,布拉席尔　丹尼斯,布拉席爾　丹尼斯,DUCLOS, OLIVIER,杜克洛　艾利维亚,杜克洛　艾利維亞,ILLIANO, STEPHANE,艾里安诺　史蒂芬妮,艾里安諾　史蒂芬妮,MALLART, SERGIO,马拉特　赛尔吉欧,馬拉特　賽爾吉歐,MARGUET, FRANK,马古特　法兰克,馬古特　法蘭克,MINOLETTI-HOCHEPIED, CLAIRE,米

摘要：: The present invention relates to a biologically active single chain Relaxin peptide having the following formula (I): Nter-Ac-(E)a-X10-E-G-R-E-X15-V-R-X18-X19-I-X21-X22-E-G-X25-S-X27-X28-X29-X30-R-(X32)b-(X33)c-(K)d-(X35)e-(gE)f-X37-Cter； or a salt or solvate thereof.It also concerns a pharmaceutical composition comprising at least one peptide of the invention, and the peptide or the pharmaceutical composition for its use as a medicament.本發明係關於具有下式(I)之生物活性單鏈鬆弛素胜肽：Nter-Ac-(E)a-X10-E-G-R-E-X15-V-R-X18-X19-I-X21-X22-E-G-X25-S-X27-X28-X29-X30-R-(X32)b-(X33)c-(K)d-(X35)e-(gE)f-X37-Cter；或其鹽或溶劑化物。其亦關於包括至少一本發明胜肽之醫藥組成物，以及其作為醫藥品用途之此胜肽或此醫藥組成物。