經修飾之鬆弛素B鏈胜肽及其治療用途农业专利-农业学术服务平台

发明人:: ILLIANO, STEPHANE,艾里安诺　史蒂芬妮,艾里安諾　史蒂芬妮,MALLART, SERGIO,马拉特　赛尔吉欧,馬拉特　賽爾吉歐,MINOLETTI-HOCHEPIED, CLAIRE,米诺莱帝　荷契皮德　克莱尔,米諾萊帝　荷契皮德　克萊爾,MARGUET, FRANK,马古特　法兰克,馬古特　法蘭克,DUCLOS, OLIVIER,杜克洛　艾利维亚,杜克洛　艾利維亞,BIANCHI

摘要：: The present invention relates to a biologically active single chain Relaxin peptide having the following formula (I): Nter-X-(E)a-X10-E-G-R-E-X15-V-R-X18-X19-I-X21-X22-E-G-X25-S-X27-X28-X29-X30-R-(X32)b-(X33)c-(X34)d-NH2-CterIt also concerns a pharmaceutical composition comprising at least one peptide of the invention, or a pharmaceutically acceptable salt or a solvate thereof, and the peptide, a pharmaceutically acceptable salt or solvate thereof, or the pharmaceutical composition, for its use as a medicament.本發明係關於具有下式(I)之生物活性單鏈鬆弛素胜肽：Nter-X-(E)a-X10-E-G-R-E-X15-V-R-X18-X19-I-X21-X22-E-G-X25-S-X27-X28-X29-X30-R-(X32)b-(X33)c-(X34)d-NH2-Cter。其亦關於包括至少一本發明胜肽，或其醫藥上可接受鹽或溶劑化物之醫藥組成物，以及此胜肽、其醫藥上可接受鹽或溶劑化物，或此醫藥組成物作為醫藥品之用途。