MAKROCIKLIČKI MCL1 INHIBITORI ZA TRETMAN RAKA

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专利权人:

ASTRAZENECA AB

发明人:

HIRD, ALEXANDER,BELMONTE, MATTHEW, ALAN,YANG, WENZHAN,SECRIST, JOHN, PAUL,ROBBINS, DANIEL, WILLIAM,KAZMIRSKI, STEVEN, LEE,WU, DEDONG,PENG, BO,JOHANNES, JEFFREY,LAMB, MICHELLE, LAURAE,YE, QING,ZHENG, X

申请号：

RSP20200549

公开号：

RS60257B1

申请日:

2017.04.21

申请国别(地区):

RS

年份:

2020

代理人:

摘要：

and enantiomers and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions of 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid, and enantiomers and pharmaceutically acceptable salts thereof, and methods of treating cancer with such compounds and compositions.

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