MACROCYCLIC MCL1 INHIBITORS FOR TREATING CANCER

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专利权人:

ASTRAZENECA AB

发明人:

HIRD, Alexander,BELMONTE, Matthew,YANG, Wenzhan,SECRIST, John,ROBBINS, Daniel,KAZMIRSKI, Steven,WU, Dedong,PENG, Bo,JOHANNES, Jeffrey,LAMB, Michelle,YE, Qing,ZHENG, Xiaolan

申请号：

SG11201805838U

公开号：

SG11201805838UA

申请日:

2017.04.21

申请国别(地区):

SG

年份:

2018

代理人:

摘要：

and enantiomers and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions of 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid, and enantiomers and pharmaceutically acceptable salts thereof, and methods of treating cancer with such compounds and compositions.

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