XIANGDONG XU,NOEL S. WILSON,ZHI WANG,LU WANG,GRIER A. WALLACE,ANIL VASUDEVAN,STACY A. VAN EPPS,JENNIFER VAN CAMP,GAGANDEEP K. SOMAL,GEORGE SHEPPARD,AUGUSTINE OSUMA,RAYMOND HUNTLEY,MICHAEL Z. HOEMANN,J
申请号：
ARP140102429
公开号：
AR101432A1
申请日:
2014.06.26
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
These compounds contribute to the treatment of immune and tumor conditions. 1. Requirement 1: a compound (1) with formula characteristics,Either a pharmaceutically acceptable salt, production, bioactive metabolite, isomer, or its stereoisomer, where x is NR 2 or s, n or CR1,Z is n or CR1；O. Is Cr12, Z is Cr12；A is n / cr830808；E is n / cr830909；R1 is independent form h, deuterium, CN, halogen, cf.8323；-No. 7580； - No. 7580；-N (R) C (O) RC₁₋₆ optionally substituted alkyl, C₂₋₆ optionally substituted alkenyl, optionally substituted aryl, C₃₋₆ optionally substituted cycloalkyl, optionally substituted C sustitu cycloalkenyl, optionally substituted heteroaryl, or optionally substituted saturated or partially saturated heterocyclyl； R² is independently H, deuterium, or C₁₋₃ optionally substituted alkyl； R³ is halogen, -N (Rᵃ) ₂,optionally substituted aryl, optionally substituted C₃₋₇ cycloalkyl, optionally substituted saturated or partially saturated heterocyclyl, or optionally substituted heteroaryl； or R³ is -R³⁰¹-L-R³⁰² where R³⁰¹ is a union, -O-,-8-832222-- No. 74966thor C₁₋₃ optionally substituted alkylene, and L is optionally substituted phenyl, C₃₋₆ optionally substituted cycloalkyl, optionally substituted heteroaryl or a saturated or partially saturated heterocyclyl containing one or more heteroatoms, at least one of which is nitrogen； or L is -L¹-L² where L¹ binds R³⁰¹ and L¹ is optionally substituted phenyl, optionally substituted heteroaryl or optionally substituted saturated or partially saturated carbocycle or saturated or partially saturated heterocyclyl； and L² is a union, CH₂,No. 74966,CH N (H)S (O) N (H)That's it.R³⁰² is CN, -CH₂CN, -C (= O) optionally substituted R³⁰²ᵃ, - (CH₂) optionally substituted saturated or partially saturated heterocyclyl or optionally substituted -S (O) ₂-C₂ alkenyl； where R³⁰²ᵃ is C₁₋₄ optionally substituted alkyl, C₂₋₄ optionally substituted alkenyl, C₂₋₄ alkynyl, -C (O) -C₁₋₄ alkyl, optionally substituted saturated or partia
