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A delayed release drug formulation comprising a coating comprising a low amylose starch and a Eudragit acrylate polymer
专利权人:
UNIVERSITY COLLEGE LONDON
发明人:
BASIT, ABDUL WASEH,IBEKWE, VALENTINE CHIDI
申请号:
NZ57276007
公开号:
NZ572760A
申请日:
2007.04.13
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is a delayed release drug formulation for delivery of a drug to the colon comprising a particle with a core A) and a coating for the core B), the core A) comprising a drug (such as prednisolone, 5-aminosalicylic acid etc.); and the coating B) comprising a mixture of (i) a first material which is susceptible to attack by colonic bacteria and which is a starch comprising no more than 75 wt % amylose; and (ii) a second material which is a film-forming polymeric material having a pH threshold at about pH 5 or above (such as a Eudragit acrylate polymer); and wherein release of the drug is delayed until the colon.
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