PROBLEM TO BE SOLVED: To provide a method for producing a percutaneous nicotine-absorbing formulation able to directly apply nicotine to an adhesive agent layer that has been impossible by conventional techniques and having little physical stimulation to the skin in peeling and good feeling in applying the formulation.SOLUTION: The method for producing the percutaneous nicotine-absorbing formulation includes a process for forming the adhesive agent layer containing an adhesive agent and a liquid component compatible with the adhesive agent on a support and a process for impregnating nicotine into the adhesive agent layer by continuously applying nicotine on the adhesive agent layer.COPYRIGHT: (C)2007,JPO&INPIT【課題】従来の技術では不可能であった、ニコチンを粘着剤層へ直接塗布することが可能なニコチン経皮吸収製剤の製造方法であって、かつ、剥離時の物理的皮膚刺激が少なく貼付感が良好な製剤の製造が可能なニコチン経皮吸収製剤の製造方法を提供すること。【解決手段】粘着剤と該粘着剤と相溶する液状成分とを含有する粘着剤層を支持体上に形成する工程と、該粘着剤層にニコチンを連続的に塗布してニコチンを粘着剤層中に含浸させる工程とを含む、ニコチン経皮吸収製剤の製造方法。【選択図】なし
