SK CHEMICALS CO., LTD.; LTD.;SK CHEMICALS CO.;에스케이케미칼주식회사
发明人:
LEE, SOO MIN,이수민,LEE, SOO HEUN,이수헌,RYU, KEUN HO,류근호,LEE, BONG YONG,이봉용,KIM, JAE SUN,김재선,OH, JUNG HOON,오정훈,JEON, YE JI,전예지
申请号：
KR1020120099712
公开号：
KR1020130028693A
申请日:
2012.09.10
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A composition containing a PDE5 inhibitor is provided to effectively improve anti-wrinkling effect. CONSTITUTION: A composition for improving anti-wrinkling effect contains a PDE5 inhibitor. The PDE5 inhibitor includes a PDE inhibitor of chemical formula 1, or a pharmaceutically acceptable salt, a solvate, or a hydrate thereof. In chemical formula 1, R^1 is hydrogen, C_1-C_3 alkyl which is substituted with one or more fluoro or non-substituted, or C_3-C_6 cycloalkyl； R^2 is hydrogen, halogen, hydroxy, C_1-C_3 alkoxy, C_3-C_6 cycloalkyl, or C_1-C_6 alkyl, C_3-C_6 cycloalkyl, C_2-C_6 alkenyl, or C_2-C_6 alkynyl which is substituted with substituted with one or more fluoro or non-substituted； and R^3 is hydrogen, hydroxy, C_1-C_3 alkoxy, C_3-C_6 cycloalkyl, or C_1-C_6 alkyl, C_3-C_6 cycloalkyl, C_2-C_6 alkenyl, or C_2-C_6 alkynyl which is substituted with one or more fluoro or non-substituted.본 발명은 피부 주름을 개선하는데 효과적인 조성물 및 이러한 조성물을 이용하는 피부 주름 개선 방법에 관한 것으로서, 포스포디에스테라제 5 (PDE5) 억제제, 바람직하게는 화학식 1의 화합물, 더욱 바람직하게는 미로데나필을 유효성분으로 포함 또는 사용하는 것을 특징으로 한다.
