The invention provides for the use of an accordion pill comprising levodopafor the treatment of symptoms ofParkinson's disease in a subject in need thereof over a 24 hour period, to beadministered to the subject in a twice dailyadministration regimen, with an interval of about 8 to about 10 hours betweenthe first dose and the second dose, and with an interval ofabout 14 to about 16 hours between the second dose and the first dose of thefollowing day. The twice daily administrationregimen provides a stable blood plasma level of levodopa in the subject aftermultiple administrations and is effective in treating thesymptoms of Parkinson's disease over a 24 hour period.
