The present disclosure is directed to a method of treating overactive bladdercomprising orally administering to a subjectin need thereof an amount of from about 50 mg to about 100 mg (e.g., about 75mg) of vibegron per day. The present disclosure alsoprovides a method of treating overactive bladder comprising orallyadministering to a subject in need thereof a first dosage of vibegronper day for a first period and a second dosage of vibegron per day thereafter.