CASHA, STEVEN,HURLBERT, JOHN,YONG, VOON WEE,BAINS, ISH,MCGOWAN, DAN,ZYGUN, DAVID
申请号：
CA2809686
公开号：
CA2809686A1
申请日:
2013.03.15
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
A dosing regime for providing therapy for a neurological trauma such as spinalcordinjury in a human subject. The dosing regime comprises intravenousadministration of aplurality of minocycline doses for a 7-day period at 12-h intervals such thata steady statelevel of minocycline is reached and maintained in a subject's serum and/orcerebrospinalfluid after adminstration of three minocycline doses. An initial minocyclinedose of at least800 mg is preferably administered within 12 h after an occurrence of theneurological trauma.The minocycline dosage is sequentially tapered to 400 mg and then maintainedat 400 mg forthe remainder of the 7-day treatment period.
