您的位置: 首页 > 农业专利 > 详情页

TREATMENT OF INFLAMMATION USING SERELAXIN
专利权人:
НОВАРТИС АГ (CH)
发明人:
УНЕМОРИ Элейн (US)
申请号:
RU2015105178
公开号:
RU2015105178A
申请日:
2013.07.29
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A method of treating inflammation, comprising administering to a subject a pharmaceutically active serelaxin at a dose effective to induce transient up-regulation of soluble ST-2 in the tissue of said subject affected by inflammation, wherein said transient up-regulation of soluble ST-2 reduces the level of pro-inflammatory cytokines in said tissue. 2. The method of claim 1, wherein said pro-inflammatory cytokines are induced by IL-33.3. A method according to claim 1, characterized in that said tissue is selected from the group consisting of lung tissue, skin tissue, articular tissue, nervous tissue and vascular tissue. A method according to claim 1, characterized in that said dose of the pharmaceutically active serelaxin varies from about 10 μg / kg / day to about 500 μg / kg / day. The method of claim 1, wherein said inflammation comprises an inflammatory disease selected from the group consisting of eosinophilic hypersensitivity of the respiratory tract, asthma, rheumatoid arthritis, multiple sclerosis (MS (MS)), ankylosing spondylitis (AS (AS)), inflammatory bowel disease, gout, myositis, Sjogren's syndrome, systemic lupus erythematosus (SLE), vasculitis, malignant pleural disease, sepsis, trauma, wound healing, atopic allergy, anaphylaxis, autoimmune encephalomyelitis, hyp central nervous system oxia, vascular damage to the central nervous system, hypernociception, eczema, dermatitis, scleroderma, poisoning caused by rooting sumac, acne, the effects of bee stings and psoriasis. 6. A method according to claim 1, characterized in that said temporary positive regulation of soluble ST-2 lasts from about 1 day to about 5 days. The method according to p. 1, characterized1. Способ лечения воспаления, включающий введение субъекту фармацевтически активного серелаксина в дозе, эффективной для индукции временной положительной регуляции растворимого ST-2 в ткани указанного субъекта, пораженной воспалением, где указанная временная положительная регуляция растворимого ST-
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充