MEDLEY, JONATHAN WILLIAM,MACHICAO TELLO, PAULO A.,LAD, LATESHKUMAR THAKORLAL,GRAUPE, MICHAEL,DU, ZHIMIN,CHO, AESOP,AKTOUDIANAKIS, EVANGELOS,ZIEBENHAUS, CHRISTOPHER ALLEN,YANG, KIN SHING,XU, JIE,WATKIN
申请号：
ARP190100340
公开号：
AR114366A1
申请日:
2019.02.12
申请国别(地区):
AR
年份:
2020
代理人:
摘要：
1. Pyridine compounds as inhibitors of PD-1, PD-L1 and / or PD-1 / PD-L1 interactions, drug components and kits containing these compounds, and their use in the treatment of various cancers and leukemia. 1. Claim 1: a formula compound (1),Among them: each n is independent of 0, 1, 2, 3 or 4； each Z1 is independent of halo-or7491；-No.8322；-Cn-7491； r7495；-No. 8323,-S（O）8322R7491；1. C833218331 and 832626；Halogenated tar c832183531832626,Alquenilo C83228331-832626；1. C 83228331 asphalt；1. O-c83218c833162622；O-c833217c8331832626 halide；e. Cicoalquilo c833223 ° 833183288o o rent c8332121883312268cyclo c83238c83318328；In this case, regardless of the oxo-no832222 category, one to four selected groups were chosen to replace the asphalt, tantalum acylate, pitch and cyclopentanyl in each group；-No. 8323,-Or7491，a. Among them, arilo, isocyanogen and isocyclic cyanide can be replaced by one to four target groups independent of halogenation and oxo-or74919；-7491，No. 8323,No.8322；-CN-Nr-S（O）8322R7491；-S（O）8322；-7491；-R74955；-No. 7491； (s (o) 8322； r7491；-No. 7491； (c) r74919；-C（O）R7491；-C（O）Or7491，-C (o) No. 7491； (r7495)； and；-No. 7491； (c) No. 7491；-No. 7491； (c) No. 1,-O-C (o) No. 7491； (r74955)； and；-No. 7491； s (o) 8322； No. 7491； r74955；-C (o) No. 7491； (s (o) 8322； 7491； r74955；1. C833218331 and 832626；Alquenilo C83228331-832626；1. C 83228331 asphalt；1.C83218331-832626-O，cycloquilo C832331-8328；1.C83218331-832626-cyclo C832383318328；a. Arilo, heterosexual, isopropene and RN, including tar, aluminum, tar, cyclopentadiene-c8331838328；Arilo, isopropene or isoacrylonitrile could be replaced by 1 to 4 target groups independent of oxo-no832222；No. 8323,-Or7491，HALO，Ciano，NR7491；R7495；-C（O）R7491；-C（O）Or7491，-O-c8321a or 83318326； (CN, - C (o) No. 7491； (r74955)；No. 7491； C (o) r7491；-No. 7491； (c) No. 7491；-S（O）8322R7491；-No. 7491； (s (o) 8322； r74955；-S（O）8322；-7491；-R74955；-No. 7491； s (o) 8322； No. 7491； r74955；-C (o) No. 7491； (s (o) 83222； No. 7491； r7495y and cycloquilo c83
