GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
DAVID MATHEW WILSON,CHRISTOPHER ROLAND WELLAWAY,ANN LOUISE WALKER,ROBERT JOHN SHEPPARD,JESSICA FANNY RENAUX,JOHN LIDDLE,NEIL STUART GARTON,CLEMENT DOUAULT,HAWA DIALLO,MATTHEW CAMPBELL,MICHAEL DAVID BA
申请号：
ARP160101486
公开号：
AR106863A1
申请日:
2016.05.20
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
Are PAD4 and Inhibitors may be useful in the treatment of various disorders, such as rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer,Cystic fibrosis, Asthma, psoriasis and cutaneous lupus erythematosus.Claim 1: a compound characterized by the formula (1), and salts thereof； wherein X is o or s, and N is r u00b9 or cr u00b2； - H OR - alkyl c u2081 u208b u2086； R u00b2 is - H, - Oh, - c u2081 u208b u2086 alkyl, alkyl - or - c u2081 u208b u2086, CN- Halo - C (= o) nh u2082, c u2081 u208b u2086 haloalquilo -, - or - c u2081 u208b u2086 c u2081 u208b u2086 alkyl or alkyl -, - or - c u2081 u208b u2086 alkyl or alkyl c u2081 u208b u2086 - Oh -, - C (= o) - O - c u2081 u208b u2086 alkyl nh u2082, - CN, - or - c u2081 u208b u2086 haloalquilo, - NH - c u2081 u208b u2086 alkylN - (heteroaryl alkyl or u2082 c u2081 u208b u2086)； r u00b3 is c u2081 u208b u2086 alkyl -, - or - c u2081 u208b u2086 nh u2082 c u2081 u208b u2086 alkyl alkyl or alkyl - c u2081 u208b u2086； r u2074 - c u2081 u208b u2086 is H, alkyl, - c u2081 u208b u2086 haloalquilo,- c u2081 u208b u2086 alkyl - (heteroaryl heteroaryl where the group is replaced with either 1, 2 or 3 groups c u2081 u208b u2086 alkyl, alkyl phenyl) - c u2081 u208b u2086 (where the phenyl Group is replaced with optional 12 or 3 substituents selected from the list of c u2081 u208b u2086 Halo, alkyl and alkyl - or - c u2081 u208b u2086) - c u2081 u208b u2086 heterociclilo - c u2081 u208b u2086 alkyl, cycloalkyl alkyl alkyl c u2081 u208b u2086 c u2083 u208b u2086, - Oh,- c u2081 u208b u2086 CN - alkyl or alkyl or alkyl - c u2081 u208b u2086 c u2081 u208b u2086； r u2075 - c u2081 u208b u2086 is H, alkyl, alkyl - or - c u2081 u208b u2086, - Oh, - Halo - ns； or r u2074 along with r u2075 are - (r u2074) ch u2082ch u2082o (r u2075) - - - - - - ch u2082ch u2082ch u2082o (r u2074) (r u2075) - or - (r u2074) - ch (i) - (r u2075), ch u2082oWhere - (r u2074) - and (- r u2075) indicate the positions of the
