ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ НАУКИ ИНСТИТУТ ФИЗИОЛОГИЧЕСКИ АКТ;FEDERALNOE GOSUDARSTVENNOE BUDZHETNOE UCHREZHDENIE NAUKI INSTITUT FIZIOLOGICHESKI AKTIVNYKH VESHCHESTV RAN (IFAV RAN)
发明人:
BACHURIN, Sergey Olegovich,БАЧУРИН, Сергей Олегович,USTUGOV, Aleksey Anatolyevich,УСТЮГОВ, Алексей Aнатольевич,NINKINA, Natalya Nikolaevna,НИНКИНА, Наталья Николаевна,SOKOLOV, Vladimir Borisovich,СОКО
申请号：
RURU2012/000894
公开号：
WO2013/070117A3
申请日:
2012.11.01
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
The claimed fluorine-containing substituted 5-[2-(pyrid-3-yl)-ethyl]-2,3,4-tetrahydro-1H-pyrido[4,3-b]indoles and hydrochlorides and hydrobromides thereof, which have the general formula (I), as agents for reducing uncontrolled protein aggregation in the nervous system, the pharmacological agent based thereon and the method for using same relate to the field of medicine and solve the problem of increasing the range of agents for combating the development of destructive processes in the central and peripheral nervous system. Formula (I), where R1 = R2 = R4 = Н, Me； or R4 + R2 = -СН2-СН2-； R3 = Н, (C1-С6) alkyl, (С2-С6) alkenyl, (Сз-С6) alkynyl, (C1-C6) alkoxy (C1-C6) alkyl, [F, Cl, Br, NO2, (C1-C6) alkyl, (C1-C6) alkoxy, acyl, (C1-C6) alkylsulfonyl, (C1- С6) alkoxycarbonyl - substituted] aryloxy (C1-C6) alkyl, (С3-С7) cycloalkyl, [F, Сl, Вr, NO2, (C1-C6) alkyl, (C1-C6) alkoxy, acyl, (C1-C6) alkylsulfonyl, (С1-С6) alkoxycarbonyl - substituted] aryl, heteryl, (C1-C6) alkylsulfonyl, (C1-C6) alkoxycarbonyl, (C1-С6) acyl, [F, Cl, Br, NO2, (С1-С6) alkyl, (C1-C6) alkoxy, acyl, (C1- С6) alkylsulfonyl, (C1-C6) alkoxycarbonyl - substituted] aroyl, heteroyl, Ν,Ν-dialkylcarbamoyl, Ν,Ν-dialkylaminosulfonyl； R5, R6, R7, R8 = H, F, Cl, Br, CN, OH, CF3, CF3O, CHF2O, NO2, (C1-C6) alkyl, (C3-C7) cycloalkyl, (C1-C6) alkoxy, [F, Cl, Br, NO2, (C1-C6) alkyl, (C1-C6) alkoxy, acyl, (C1-C6) alkylsulfonyl, (C1-C6) alkoxycarbonyl - substituted] aryl, [F, Cl, Br, NO2, (C1-C6) alkyl, (C1-С6) alkoxy, acyl, (C1-C6) alkylsulfonyl, (C1-C6) alkoxycarbonyl - substituted] aryloxy, (Me, Cl, Br - substituted) pyridyl, (C1-C6) alkylsulfonyl, (C1- С6) alkoxycarbonyl, (C1-C6) acyl, [F, Cl, Br, NO2, (C1-C6) alkyl, (C1-C6) alkoxy, acyl, (C1-C6) alkylsulfonyl, (C1-C6) alkoxycarbonyl - substituted] aroyl, Ν,Ν-dialkylcarbamoyl, Ν,Ν-dialkylaminosulfonyl； R9 = F, 2F, CHF2, CC1F2, CF3.； X = nothing, Cl. Br.L'invention concerne des 5-[2-(pyrid-3-yl)-éthyl]-2,3,4-tétrahydro-1H-pyrido[4,3-b]indoles fluorés substitués,
