FLUORINE CONTAINING SUBSTITUTED 5- [2- (PYRID-3-IL) -ETHYL] -2,3,4-TETRAHYDRO-1H-PYRIDO [4,3-b] INDOLES, THEIR CHLOROHYDRATES AND BROMHYDRATES AS A LOW REDUCER NERVOUS SYSTEM, PHARMACOLOGICAL MEANS ON THEIR BASIS AND METHOD OF ITS APPLICATION
Федеральное государственное бюджетное учреждение науки Институт физиологически активных веществ Российской академии наук (ИФАВ РАН) (RU)
发明人:
Бачурин Сергей Олегович (RU),Устюгов Алексей Анатольевич (RU),Нинкина Наталья Николаевна (RU),Соколов Владимир Борисович (RU),Аксиненко Алексей Юрьевич (RU),Шелковникова Татьяна Александровна (RU),Бол
申请号：
RU2011145513/04
公开号：
RU2011145513A
申请日:
2011.11.10
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. Fluorine-substituted 5- [2- (pyrid-3-yl) ethyl] -2,3,4-tetrahydro-1H-pyrido [4,3-b] indoles, their hydrochlorides and bromohydrates, of the general formula 1 as agents for reducing uncontrolled aggregation of proteins in the nervous system (I) where R = R = R = H, Me or R + R = -CH-CH-； R = H, (CC) alkyl, (CC) alkenyl, (CC) alkynyl , (CC) alkoxy (C — C) alkyl, [F, Cl, Br, NO, (C — C) alkyl, (C — C) alkoxy, acyl, (C — C) alkylsulfonyl, (C — C) alkoxycarbonyl substituted ] aryloxy (С-С) alkyl, (CC) cycloalkyl, [F, Cl, Br, NO, (С-С) alkyl, (С-С) alkoxy, acyl, (С-С) alkylsulfonyl, (С-С ) alkoxycarbonyl substituted] aryl, heteryl, (C — C) alkylsul phonyl, (C — C) alkoxycarbonyl, (C — C) acyl, [F, Cl, Br, NO, (C — C) alkyl, (C — C) alkoxy, acyl, (C — C) alkylsulfonyl, (C -C) alkoxycarbonyl substituted] aroyl, heteroil, N, N-dialkylcarbamoyl, N, N-dialkylaminosulfonyl； R, R, R, R = H, F, Cl, Br, CN, OH, CF, CFO, CHFO, NO, ( CC) alkyl, (CC) cycloalkyl, (CC) alkoxy, [F, Cl, Br, NO, (C — C) alkyl, (C — C) alkoxy, acyl, (C — C) alkylsulfonyl, (C — C ) alkoxycarbonyl substituted] aryl, [F, Cl, Br, NO, (C-C) alkyl, (C-C) alkoxy, acyl, (C-C) alkylsulfonyl, (C-C) alkoxycarbonyl-substituted] aryloxy, (Me, Cl , Br - substituted) pyridyl, (C — C) alkylsulfonyl, (C — C) alkoxycarbonyl, (C — C) acyl, [F, Cl, Br, NO, ( C-C) alkyl, (C-C) alkoxy, acyl, (C-C) alkylsulfonyl, (C-C) alkoxycarbonyl-substituted] aroyl, N, N-dialkylcarbamoyl, N, N-dialkylaminosulfonyl； R = F, 2F, CHF , CClF, CF； X = no, Cl, Br. 2. A pharmacological agent for reducing uncontrolled aggregation of proteins in the nervous system, containing an active principle and a pharmaceutically acceptable carrier, characterized in that it contains an effective amount of a compound of formula (1) as an active principle. 3. A method of reducing the uncontrolled aggregation of proteins in the nervous system, which consists in the introduction of pharmacol to the patient1. Фторсодержащие замещенные 5-[2-(пирид-3-ил)-этил]-2,3,4-
