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FLUORHALTIGE [5- (2-PYRID-3-YL) -ETHYL] -2,3,4-TETRAHYDRO-1H-PYRIDO [4,3-B]INDOLE ALS MITTEL ZUR VERRINGERUNG VON UNKONTROLLIERTER PROTEINAGGREGATION
- 专利权人:
- FEDERALNOE GOSUDARSTVENNOE BYDZHETNOE UCHREZHDENIE NAUKI INSTITUT FIZIOLOGICHESKI AKTIVNIKH VESCHESTV ROSSIISKOI AKADEMII NAUK (IFAV RAN)
- 发明人:
- BACHURIN, SERGEY OLEGOVICH,USTUGOV, ALEKSEY ANATOLYEVICH,NINKINA, NATALYA NIKOLAEVNA,SOKOLOV, VLADIMIR BORISOVICH,AKSINENKO, ALEKSEY YURYEVICH,SHELKOVNIKOVA, TATYANA ALEKSANDROVNA,BOLKUNOV, ALEKSEY VI
- 申请号：
- EP12848204
- 公开号：
- EP2781518A4
- 申请日:
- 2012.11.01
- 申请国别(地区):
- EP
- 年份:
- 2015
- 代理人:
- 摘要：
- The claimed fluorine-containing substituted 5-[2-(pyrid-3-yl)-ethyl]-2,3,4-tetrahydro-1H-pyrido[4,3-b]indoles and hydrochlorides and hydrobromides thereof, which have the general formula (I), as agents for reducing uncontrolled protein aggregation in the nervous system, the pharmacological agent based thereon and the method for using same relate to the field of medicine and solve the problem of increasing the range of agents for combating the development of destructive processes in the central and peripheral nervous system. where R 1 = R 2 = R 4 = H, Me； or R 4 + R 2 = -CH 2 -CH 2 -； R 3 = H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 3 -C 6 )alkynyl, (C 1 -C 6 )alkoxy (C 1 -C 6 )alkyl, [F, Cl, Br, NO 2 , (C 1 -C 6 )alkyl, (C 1 -C 6 ) alkoxy, acyl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 )alkoxycarbonyl - substituted] aryloxy (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, [F, Cl, Br, NO 2 , (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, acyl, (C 1 -C 6 ) alkylsulfonyl, (C 1 -C 6 )alkoxycarbonyl - substituted] aryl, heteryl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 )alkoxycarbonyl, (C 1 -C 6 ) acyl, [F, Cl, Br, NO 2 , (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, acyl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 )alkoxycarbonyl - substituted] aroyl, heteroyl, N,N-dialkylcarbamoyl, N,N-dialkylaminosulfonyl； R 5 , R 6 , R 7 , R 8 = H, F, Cl, Br, CN, OH, CF 3 , CF 3 O, CHF 2 O, NO 2 , (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, (C 1 -C 6 )alkoxy, [F, Cl, Br, NO 2 , (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, acyl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 ) alkoxycarbonyl - substituted] aryl, [F, Cl, Br, NO 2 , (C 1 -C 6 ) alkyl, (C 1 -C 6 )alkoxy, acyl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 ) alkoxycarbonyl - substituted] aryloxy, (Me, Cl, Br - substituted) pyridyl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 ) alkoxycarbonyl, (C 1 -C 6 )acyl, [F, Cl, Br, NO 2 , (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, acyl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 )alkoxycarbonyl - substituted] aroyl, N,N-dialkylcarbamoyl, N,N-dialkylaminosulfonyl
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
