The United States of America; as represented by the Secretary; Department of Health and Human Services
发明人:
Neckers, Leonard M.,Cox, Marc B.,Neckers, Jane B.,Kim, Yeong Sang,Iwai, Aki,Ning, Yangmin,De Leon, Johanny Meneses,Balsiger, Heather A.,Fletterick, Robert
申请号：
AU2014200360
公开号：
AU2014200360A1
申请日:
2014.01.21
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
#$%^&*AU2014200360A120140206.pdf#####33 ABSTRACT: Pharmaceutical compositions that bind to a predicted FK506 Binding Protein 52 (FKBP52) interaction surface on the androgen receptor hormone binding domain, otherwise known as FKBP52 Targeting Agents (FTAs) are 5 provided. These compositions of the present invention are found to specifically recognise the FKBP52 regulatory surface on the androgen receptor and inhibit FKBP52 from functionally interacting with the androgen receptor. Compositions comprising the pharmaceutical composition, as well as methods of use, treatment and screening are also provided. Document53Dccument531/9 FIGURE 1 A. 8. 200 C806Y 100 K8456 RSL* AR + vector 50. AR + 52 - AR mutant + vector R840 ARmutan+2 P721 100 260 30 40D 0 600 DHT (nM)
