Berrin Erda{hacek over (g)},Bertan Koray Balcio{hacek over (g)}lu,Aylin Ozdemir Bahadir,Aydin Bahar,Kemal Baysal,Müge Serhatli,Omer Kaçar,Türker Kiliç,Emel Akgün,Abdulkadir Özkan
申请号：
US13808295
公开号：
US09193792B2
申请日:
2010.07.07
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Phage displayed recombinant antibody library was developed and the library was screened against VEGFR-2. After screening and ELISA experiments two recombinant antibodies showing binding properties to VEGFR-2 was obtained. The difference of the two recombinant antibodies to the recombinant antibodies already developed was demonstrated by DNA sequence analysis. The inhibition effect of the two recombinant antibodies on endothelial cell proliferation was demonstrated with cell assays. Thus these recombinant antibodies might be used as VEGF related angiogenesis inhibitors.
