The United States of America, as represented by the Secretary, Department of Health and Human Services;The Regents of the University of California, a California Corporation;Board of Regents, The Unive
发明人:
Leonard M. Neckers,Marc B. Cox,Jane B. Neckers,Yeong Sang Kim,Aki Iwai,Yangmin Ning,Johanny Kugelman-Tonos,Heather A. Balsiger,Robert Fletterick
申请号：
US14955505
公开号：
US09782399B2
申请日:
2015.12.01
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Pharmaceutical compositions that bind to a predicted FK506 Binding Protein 52 (FKBP52) interaction surface on the androgen receptor hormone binding domain, otherwise known as FKBP52 Targeting Agents (FTAs) are provided. These compositions of the present invention are found to specifically recognize the FKBP52 regulatory surface on the androgen receptor and inhibit FKBP52 from functionally interacting with the androgen receptor. Compositions comprising the pharmaceutical composition, as well as methods of use, treatment and screening are also provided.
